

Exactly.
Or even- no known hallucinogens synthesized by their canonical biochemical pathways by enzymes expressed from the host species genome.
The OG hallucinogen, ergot, is ingested by eating wheat. If one presumed that the substance is made by wheat, and mined the wheat genome, they would never find the genes for its synthesis, because the hallucinogen is made by mold growing on the wheat.
It’s very rare you can draw a strong conclusion from negative results.

Mackaques love touchscreens, amd can be trained to do complex tasks on tablets placed in their enclosures.
You make a test where they need to press a button when and only when they see tiny monkeys that you can project on a screen or on their floor.
Then you give the drug at various concentrations and placebo, and see if there is a dose dependent increase in the monkeys indicaions of mini monkeys.
Then you can repeat the experiment after treatment with antipsychotic, if it prevents the mini monkey reporting, you already have a hint at the mechanism.
Any nonhuman primate lab can do this from 1-2 million dollars, should we start a go fund me?