Want to wade into the snowy surf of the abyss? Have a sneer percolating in your system but not enough time/energy to make a whole post about it? Go forth and be mid: Welcome to the Stubsack, your first port of call for learning fresh Awful you’ll near-instantly regret.
Any awful.systems sub may be subsneered in this subthread, techtakes or no.
If your sneer seems higher quality than you thought, feel free to cut’n’paste it into its own post — there’s no quota for posting and the bar really isn’t that high.
The post Xitter web has spawned soo many “esoteric” right wing freaks, but there’s no appropriate sneer-space for them. I’m talking redscare-ish, reality challenged “culture critics” who write about everything but understand nothing. I’m talking about reply-guys who make the same 6 tweets about the same 3 subjects. They’re inescapable at this point, yet I don’t see them mocked (as much as they should be)
Like, there was one dude a while back who insisted that women couldn’t be surgeons because they didn’t believe in the moon or in stars? I think each and every one of these guys is uniquely fucked up and if I can’t escape them, I would love to sneer at them.
(Credit and/or blame to David Gerard for starting this. Merry Christmas, happy Hannukah, and happy holidays in general!)
elsewhere on lemmy, a piece from the atlantic (be warned: they quote lasker/cremieux for some reason) on new shiny glp-1 agonist that you can order off telegram from some random ass chinese lab:
isn’t dear leader EY taking this? it’s still not approved yet, so it’s not available on normal market, and because it’s peptide it’s i.m. only. also, side effects not just for this one, but for entire class include anhedonia, which must be very rational thing to risk without medical need. chat, what’s your p(infected sore on EY’s ass)
this is the cheapass one they sell on ali
I’m running ozempic and I haven’t noticed any anhedonia tbf. I think Yud claimed he had tried them and that they failed to work or something.
@saucerwizard Do you drink alcohol, and if so, what has semaglutide done to your desire to drink? (I know my alcohol consumption crashed by about 80% when I went on Rybelsus—the oral formulation of semaglutide, the GLP-1 agonist in Ozempic™—and it’s a common enough side-effect that it’s undergoing clinical trials as an anti-addiction medication.)
Its gone completely out the window - anything more then a beer or two and I get nauseous. I get a free bottle of hard liquor from work every quarter (distillery) and I’m completely unable to touch the stuff now.
I also quit marijuana entirely, the only thing remaining is nicotine (which I do consider dropping from time to time). All and all, I think its been a good thing since I’m not sure I have the healthiest relationship with substances.
@saucerwizard I still drink *socially*, but it’s very much an “I’ll have a pint or two at the pub where I’m going to see friends”, rather than “I’m going to the pub for a drink (with friends)”. And zero inclination to drink at home, even with meals. Not that I did so regularly before, but semaglutide caused a marked loss of interest on my part.
I was *really* worried for the first six months that it had nuked my pleasure in writing, which would have been a disaster—it’s my job—but I recovered.
good for you ig. ozempic is actually small enough (and profitable enough) to make it synthetically, but novo process is to make linear precursor by fermentation, purify that, then tack on it side chain and N-terminal H-His-Aib- using regular peptide chemistry methods. no such luck with retatrutide tho, it has to be entirely synthetic. the real big deal however will be about small-molecule drug that targets this receptor, because this means pills instead of injections from day 1