6 years of python and I’ve never really had that problem, also working on larger projects. Use poetry or uv and you’ll probably be fine.
Unless you’re doing something strange with your dependencies.
The only thing I would say is non trivial is updating the dependencies. And if a library has a bug or something you have to downgrade for.
You can specify dev dependencies for notebooks and such.
I’ve not heard of mlflow having a problem with a manager. Perhaps you’re in a cloud environment and don’t have access to poetry for example?
6 years of python and I’ve never really had that problem, also working on larger projects. Use poetry or uv and you’ll probably be fine. Unless you’re doing something strange with your dependencies. The only thing I would say is non trivial is updating the dependencies. And if a library has a bug or something you have to downgrade for. You can specify dev dependencies for notebooks and such. I’ve not heard of mlflow having a problem with a manager. Perhaps you’re in a cloud environment and don’t have access to poetry for example?