wow there a lot of fascinating stories here: https://en.wikipedia.org/wiki/Spanish_assault_on_French_Florida

among other little tidbits:

On 20 July, 1565, the English adventurer John Hawkins arrived at the fort with his fleet … The French introduced Hawkins to tobacco, which they all were using, and in turn he introduced it to England upon his return.

https://en.wikipedia.org/wiki/Fort_Caroline