Disclaimer: This LitRPG comedy about a shapeshifter is a work of fiction. 😇👍
Possibly interesting: The following placebo-controlled clinical trials were for drugs that inhibited the microglial pathways (via p38 MAPK inhibitors and minocycline). They all failed:
There’s a problem with all of them: They failed to disaggregate results based on sex, which is exactly the problem I was talking about when I said “(we) need to account for (sex in medical studies)” earlier. This leads me to believe that these pain medications could have been useful for men, but probably not for women if the mouse studies indicating different pain pathways for each sex apply to humans.
Historically, research has assumed a largely “sex-neutral” model of pain. Yet mounting evidence demonstrates that men and women differ substantially in pain perception, processing, and response to treatment (7–9). These differences span the entire biopsychosocial spectrum, including neural circuitry, immune function, hormonal regulation, genetics, and social context (10). Understanding these distinctions is critical, as failure to account for sex as a biological variable risks overlooking mechanisms unique to half of the population and may lead to suboptimal or even harmful therapeutic approaches.
Sure!
Disclaimer: This LitRPG comedy about a shapeshifter is a work of fiction. 😇👍
Possibly interesting: The following placebo-controlled clinical trials were for drugs that inhibited the microglial pathways (via p38 MAPK inhibitors and minocycline). They all failed:
There’s a problem with all of them: They failed to disaggregate results based on sex, which is exactly the problem I was talking about when I said “(we) need to account for (sex in medical studies)” earlier. This leads me to believe that these pain medications could have been useful for men, but probably not for women if the mouse studies indicating different pain pathways for each sex apply to humans.
There’s a whole article about this: https://doi.org/10.3389/fneur.2025.1730291